Synthesis of Immunogenic Glycolipids to Enhance the Effects of Chemotherapeutics
Our one-pot strategies for making glycolipids are based upon the remarkable reactivity profile of glycosyl iodides. Once thought to be too reactive to be of synthetic value, studies from our lab and a few others throughout the world indicate quite the contrary. In fact, the unique reactivity of glycosyl iodides allows them to be generated in a single step from anomeric silyl ethers and subsequently reacted with fully functionalized ceramide, cholesterol and glycerol ester acceptors to provide immunogenic glycolipids with remarkable stereocontrol. This streamlined synthetic platform has enabled us to provide these materials to researchers throughout the world who are interested in characterizing the immunogenicity profiles of glycolipids.
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