During the past eleven years, our work has focused on HIV infection and cancer metastasis as biological targets. While these may seem like two very different diseases, our studies indicate that both can be addressed using similar chemical strategies. Our research is rooted in three core areas including 1) the development of small molecule inhibitors of critical pathogenic pathways, 2) synthesis of chemically defined macromolecules as vaccine candidates and, 3) the synthesis of immunogenic glycolipids to enhance the effects of chemotherapeutics.
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d. Gervay-Hague J, DeNardo S, Du W, Natarajan A., inventors. The Regents of the University of California (Oakland, CA), assignee. Construction of a multivalent scFv through alkyne-azide 1,3- dipolar cycloaddition. US 8,946,391. 2015 February 03.
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